Necrobiosis Lipoidica (NL) is a rare, painful condition affecting the skin and tissue under the skin; it typically affects the lower legs. This is no known cause for NL. NL usually appears as patches, or lesions, on the lower legs or shins; it can also appear elsewhere on the body – such as on the upper legs, hands, arms, torso, face or scalp – though this is rare. People with NL may notice one or more shiny, raised, flushed patches of skin on their lower legs that may be itchy or painful. The centers of the patches may become pale with visible blood vessels. Ulcerations occur in up to 30% of patients with NL. Ulcerations often prove challenging to treat and may lead to more severe complications. There is no one treatment that works for everyone and the condition is chronic. There are currently no FDA-approved drugs to treat NL. The ulcers in NL can be painful leading to impaired quality of life for many people. NL lesions are caused by a number of factors which has made it difficult to develop an effective treatment for this condition.
Estimated NL patients in the U.S.
Estimated NL patients worldwide